MOVANTIK is a prescription medicine used to treat constipation that is caused by prescription pain medicines called opioids, in adults with long-lasting (chronic) pain that is not caused by active cancer.

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Explore the MOVANTIK Patient Brochure.

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  • MOVANTIK may cause serious side effects, including:
    • Opioid withdrawal. You may have symptoms of opioid withdrawal during treatment with MOVANTIK, including sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning. Patients taking methadone to treat their pain may be more likely to experience stomach pain and diarrhea. Tell your doctor if you have any of these symptoms
    • Severe Stomach Pain and/or Diarrhea. This can happen within a few days of starting MOVANTIK and can lead to hospitalization. If either of these side effects occurs, stop taking MOVANTIK and call your doctor immediately
    • Tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that gets worse or does not go away, stop taking MOVANTIK and get emergency medical help right away
  • Do not take MOVANTIK if you:
    • Have a bowel blockage (intestinal obstruction) or have a history of bowel blockage
    • Are allergic to MOVANTIK or any of the ingredients in MOVANTIK
  • MOVANTIK can interact with other medicines and cause side effects, including opioid withdrawal symptoms (see symptoms above). Tell your doctor or pharmacist before you start or stop any medicines during treatment with MOVANTIK
  • Before you take MOVANTIK, tell your doctor about all of your medical conditions, including if you:
    • Have any stomach, bowel (intestines) problems, including inflammation in parts of the large intestine (diverticulitis), or inflammation and injury of the intestines caused by reduced blood flow (ischemic colitis)
    • Have had recent surgery on the stomach or intestines
    • Have any kidney, or liver problems
    • Are pregnant or plan to become pregnant. Taking MOVANTIK during pregnancy may cause opioid withdrawal symptoms in you or your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with MOVANTIK
    • Are breastfeeding or plan to breastfeed. It is not known if MOVANTIK passes into your breast milk. Taking MOVANTIK while you are breastfeeding may cause opioid withdrawal in your baby. You and your healthcare provider should decide if you will take MOVANTIK or breastfeed. You should not breastfeed if you take MOVANTIK
  • Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect the way MOVANTIK works
  • If you stop taking your opioid pain medicine, stop taking MOVANTIK and tell your doctor
  • Avoid eating grapefruit or drinking grapefruit juice during treatment with MOVANTIK
  • The most common side effects of MOVANTIK include: Stomach (abdomen) pain, diarrhea, nausea, gas, vomiting, headache, and excessive sweating

MOVANTIK is a prescription medicine used to treat constipation that is caused by prescription pain medicines called opioids, in adults with long-lasting (chronic) pain that is not caused by active cancer.

Click here for the Medication Guide and full Prescribing Information for MOVANTIK.

You are encouraged to report Adverse Reactions to RedHill Biopharma Inc. at 1-833-ADRHILL (1-833-237-4455) or FDA at 1-800-FDA-1088 or

RedHill Biopharma Inc. supports the responsible use of medications, including those containing opioids, as treatment options for patients with chronic non-cancer pain.

This site is intended for US Consumers only.

The information on this website should not take the place of talking with your doctor or health care professional. If you have any questions about your condition, or if you would like more information about MOVANTIK, or about constipation caused by opioid use for chronic non-cancer pain, talk to your doctor or pharmacist. Only you and your doctor can decide if MOVANTIK is right for you.

RedHill Biopharma Inc. (U.S. Office)
8041 Arco Corporate Drive, Suite 200
Raleigh, NC 27617
Tel: +1-984-444-7010
Fax: +1-919-406-0400

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Think you have opioid-induced constipation?

Think you have opioid-induced constipation?

Begin the quiz

Are you currently taking any opioid pain medication(s) for chronic non-cancer pain?

Select one

Not sure

MOVANTIK is meant for people taking opioids in order to treat opioid-induced constipation in adults with chronic non-cancer pain.

If you’re experiencing constipation, talk to your doctor about your options for treatment.2,3

Go back

How many bowel movements do you have per week?

Select one

4 or more

MOVANTIK is for the treatment of opioid-induced constipation in adults with chronic non-cancer pain. Having less than 3 bowel movements per week while taking opioids can be a symptom of opioid-induced constipation.

If you’re experiencing constipation, talk to your doctor
about your options for treatment.2,3

Go back

When completing a bowel movement, have you experienced any of the following?

Select all that apply

Hard or lumpy
Sense of incomplete evacuation

You may have opioid-induced constipation.1-3

Talk to you doctor about your symptoms and learn how
MOVANTIK may be able to help.

References: 1. Brock C, Olesen SS, Olesen AE, Frøkjaer JB, Andresen T, Drewes AM. Opioid-induced bowel dysfunction: pathophysiology and management. Drugs. 2012;72:1847-1865. 2. MOVANTIK® (naloxegol). Prescribing information. RedHill Biopharma Inc; 2020. 3. Chey WD, Webster L, Sostek M, Lappalainen J, Barker PN, Tack J. Naloxegol for opioid-induced constipation in patients with noncancer pain. N Engl J Med. 2014;370:2387-2396.

Coverage for the #1 prescribed oral
PAMORA just got even better1

*Data as of June 2021.3

Plans and coverage may vary and are subject to change. General information only, not a guarantee of coverage. Coverage and status do not imply efficacy or safety.

PAMORA=peripherally acting mu-opioid receptor antagonist; PDP=prescription drug plan.

References: 1. Data on file. Prescription data. RedHill Biopharma Inc; 2021. 2. Data on file. Prime Therapeutics formulary coverage. RedHill Biopharma Inc; 2021. 3. Data on file. Cigna formulary coverage. RedHill Biopharma Inc; 2021.


  • MOVANTIK® (naloxegol) is contraindicated in:
    • Patients with known or suspected gastrointestinal (GI) obstruction and patients at risk of recurrent obstruction, due to the potential for GI perforation
    • Patients receiving strong CYP3A4 inhibitors (eg, clarithromycin, ketoconazole) because these medications can significantly increase exposure to naloxegol which may precipitate opioid withdrawal symptoms

Click here for additional Important Safety Information and full Prescribing Information for MOVANTIK.