Frequently Asked Questions

Opioid-Induced Constipation

“OIC” stands for “opioid-induced constipation,” which is a specific type of constipation caused by opioids. Opioids are prescription medicines like codeine, hydrocodone, morphine, oxycodone, fentanyl, and tramadol that are used to treat pain.

OIC is one of the most common side effects of opioids. It can happen when someone starts taking prescription opioids for long-lasting (chronic) non-cancer pain and can last as long as they’re taking them.

Opioids block pain signals by attaching to something called mu-receptors in the brain and other parts of the central nervous system. But opioids also attach to mu-receptors in the bowel, which can cause OIC.
More about OIC>

MOVANTIK

MOVANTIK is a prescription medicine used to treat constipation that is caused by prescription pain medicines called opioids, in adults with long lasting (chronic) pain that is not caused by active cancer.

MOVANTIK one pill once a day is specifically designed for OIC in adults with chronic non-cancer pain. It works by blocking opioids from binding to something called mu-receptors in your bowel.

More about MOVANTIK>
More about OIC>

In clinical studies, MOVANTIK worked quickly, often within 6 to 12 hours of the first dose.

More about MOVANTIK>

MOVANTIK is a prescription treatment specifically for constipation from opioids in adults with long-lasting (chronic) pain that is not caused by active cancer.

Over-the-counter (OTC) laxatives are labeled for occasional constipation.

More about MOVANTIK>

When starting MOVANTIK, changes to your opioid dosing regimen are not required. It’s important to talk to your doctor about your pain management and opioid dose.

MOVANTIK may cause serious side effects, including:

Opioid withdrawal.

  • You may have symptoms of opioid withdrawal during treatment with MOVANTIK including sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning. If you take methadone to treat your pain, you may be more likely to have stomach pain and diarrhea than people who do not take methadone. Tell your health care provider if you have any of these symptoms

Severe stomach pain or diarrhea, or both severe stomach pain and diarrhea.

  • Severe stomach pain and diarrhea can happen when you take MOVANTIK. These problems can happen within a few days after you start taking MOVANTIK and can lead to hospitalization. Stop taking MOVANTIK and call your healthcare provider right away if you have severe stomach pain or diarrhea, or both severe stomach pain and diarrhea.

Tear in your stomach or intestinal wall (perforation).

  • Stomach pain that is severe can be a sign of a serious medical condition. If you have stomach pain that gets worse or does not go away, stop taking MOVANTIK and get emergency medical help right away

The most common side effects of MOVANTIK include: stomach (abdomen) pain, diarrhea, nausea, gas, vomiting, and headache.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of MOVANTIK.

Call your doctor for medical advice about side effects.

Please see Important Safety InformationMedication Guide, and US Full Prescribing Information.

You should take MOVANTIK exactly as your health care provider tells you. Be sure to take your prescribed dose of MOVANTIK 1 time each day, on an empty stomach, at least 1 hour before your first meal of the day or 2 hours after the meal. You should also stop taking other laxatives before you start treatment with MOVANTIK. Your health care provider may prescribe other laxatives if MOVANTIK does not work after 3 days of treatment.

Savings

The majority of commercial patients* nationwide are covered for MOVANTIK. Ask your pharmacist or check with your insurance provider.

*“Patients” means covered lives (Commercial, Commercial [BCBS], Employer, Federal Employees Health Benefit Plans [FEHBPs], Federal Programs, Municipal Plan, Pharmacy Benefit Manager [PBM], Union) at Tiers 1-7 and the $0 Co-pay tier in the region, as calculated by Managed Markets Insight & Technology, LLC database as of June 24, 2020.

“Covered” means any coverage level, specifically Tiers 1-7 and the $0 Co-pay tier, regardless of restrictions.

With the MOVANTIK Savings Card, eligible patients pay as little as $0 per month,* a cost less than OTC laxatives.†‡

How to save on MOVANTIK>

*Subject to eligibility. Restrictions apply. See savings page of this website for eligibility information and instructions. If eligible, show your card and prescription to your pharmacist for instant savings.

OTC laxatives include Colace®, Dulcolax®, ex-lax®, MiraLAX®, Peri-Colace®, Senokot®, and Senokot-S®.

Pricing comparisons do not imply comparable efficacy, safety, or FDA-approved indications.

If you’re eligible, you can pay as little as $0 per month with the MOVANTIK Savings Card.

Click here to learn more about the MOVANTIK Savings Card>

ELIGIBILITY:

You may be eligible for this offer if you are insured by commercial insurance and your insurance does not cover the full cost of your prescription, or you are not insured and are responsible for the cost of your prescriptions.

Patients who are enrolled in a state or federally funded prescription insurance program are not eligible for this offer. This includes patients enrolled in Medicare Part D, Medicaid, Medigap, Veterans Affairs (VA), Department of Defense (DOD) programs or TriCare, and patients who are Medicare eligible and enrolled in an employer-sponsored group waiver health plan or government-subsidized prescription drug benefit program for retirees.

If you are enrolled in a state or federally funded prescription insurance program, you may not use this Savings Card even if you elect to be processed as an uninsured (cash-paying) patient.

This offer is not insurance and is restricted to residents of the United States and Puerto Rico and patients over 18 years of age. This offer is valid for retail prescriptions only.

TERMS OF USE:

Eligible commercially insured patients with a valid prescription for MOVANTIK® (naloxegol) Tablets who present this Savings Card at participating pharmacies will pay $0 per 30-day supply, subject to a maximum savings of $100 per 30-day supply. Cash-paying patients will receive up to $100 in savings on out-of-pocket costs that exceed $0 per 30-day supply. This offer is good for 12 uses and each 30-day supply counts as 1 use. Other restrictions may apply. Patient is responsible for applicable taxes, if any. If you have any questions regarding this offer, please call 1-984-444-7010.

Offer expires on 12/31/2020.

Non-transferable, limited to one per person, cannot be combined with any other offer. Void where prohibited by law, taxed, or restricted. Patients, pharmacists, and prescribers cannot seek reimbursement from health insurance or any third party for any part of the benefit received by the patient through this offer. RedHill Biopharma reserves the right to rescind, revoke, or amend this offer, eligibility, and terms of use at any time without notice. This offer is not conditioned on any past, present, or future purchase, including refills. Offer must be presented along with a valid prescription for MOVANTIK® (naloxegol) Tablets at the time of purchase.

BY USING THIS CARD, YOU AND YOUR PHARMACIST UNDERSTAND AND AGREE TO COMPLY WITH THESE ELIGIBILITY REQUIREMENTS AND TERMS OF USE.

Program managed by ConnectiveRx on behalf of RedHill Biopharma.

IMPORTANT SAFETY INFORMATION ABOUT MOVANTIK

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  • MOVANTIK may cause serious side effects, including:
    • Opioid withdrawal. You may have symptoms of opioid withdrawal during treatment with MOVANTIK, including sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning. Patients taking methadone to treat their pain may be more likely to experience stomach pain and diarrhea. Tell your doctor if you have any of these symptoms
    • Severe Stomach Pain and/or Diarrhea. This can happen within a few days of starting MOVANTIK and can lead to hospitalization. If either of these side effects occurs, stop taking MOVANTIK and call your doctor immediately
    • Tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that gets worse or does not go away, stop taking MOVANTIK and get emergency medical help right away
  • Do not take MOVANTIK if you:
    • Have a bowel blockage (intestinal obstruction) or have a history of bowel blockage
    • Are allergic to MOVANTIK or any of the ingredients in MOVANTIK
  • MOVANTIK can interact with other medicines and cause side effects, including opioid withdrawal symptoms (see symptoms above). Tell your doctor or pharmacist before you start or stop any medicines during treatment with MOVANTIK
  • Before you take MOVANTIK, tell your doctor about all of your medical conditions, including if you:
    • Have any stomach, bowel (intestines) problems, including inflammation in parts of the large intestine (diverticulitis), or inflammation and injury of the intestines caused by reduced blood flow (ischemic colitis)
    • Have had recent surgery on the stomach or intestines
    • Have any kidney, or liver problems
    • Are pregnant or plan to become pregnant. Taking MOVANTIK during pregnancy may cause opioid withdrawal symptoms in you or your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with MOVANTIK
    • Are breastfeeding or plan to breastfeed. It is not known if MOVANTIK passes into your breast milk. Taking MOVANTIK while you are breastfeeding may cause opioid withdrawal in your baby. You and your healthcare provider should decide if you will take MOVANTIK or breastfeed. You should not breastfeed if you take MOVANTIK
  • Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect the way MOVANTIK works
  • If you stop taking your opioid pain medicine, stop taking MOVANTIK and tell your doctor
  • Avoid eating grapefruit or drinking grapefruit juice during treatment with MOVANTIK
  • The most common side effects of MOVANTIK include: Stomach (abdomen) pain, diarrhea, nausea, gas, vomiting, headache, and excessive sweating

APPROVED USE FOR MOVANTIK

MOVANTIK is a prescription medicine used to treat constipation that is caused by prescription pain medicines called opioids, in adults with long-lasting (chronic) pain that is not caused by active cancer.

You are encouraged to report Adverse Reactions to RedHill Biopharma Inc. at 1-833-ADRHILL (1-833-237-4455) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.