APPROVED USE FOR MOVANTIK
MOVANTIK is a prescription medicine used to treat constipation that is caused by prescription pain medicines called opioids, in adults with long-lasting (chronic) pain that is not caused by active cancer.
Rapid response with MOVANTIK—AM to PM
In 2 clinical studies, MOVANTIK worked quickly—often within 6 to 12 hours of the first dose1
MOVANTIK is taken once a day in the morning, on an empty stomach,* for the duration of opioid treatment.1
In the same 2 studies, response rate for MOVANTIK was 40% to 44% with a 25 mg dose and 35% to 41% with a 12.5 mg dose.1
ask your doctor about MOVANTIK
Study Design: A total of 652 patients in KODIAC-04 and 700 patients in KODIAC-05, aged 18 to 84 years (mean age 52 years), with chronic non-cancer pain and opioid-induced constipation, were randomized to take MOVANTIK 12.5 mg, MOVANTIK 25 mg, or placebo once daily for 12 weeks. The patients who participated in KODIAC-04 and KODIAC-05 were taking a wide range of opioids. Before study enrollment, patients had been using their current opioid for an average of 3.6 and 3.7 years. Primary endpoint was response rate, defined as ≥3 spontaneous bowel movements per week (without use of rescue laxative in the previous 24 hours) and ≥1 spontaneous bowel movement per week over baseline.1,2
*At least 1 hour prior to the first meal of the day or 2 hours after the meal. Consumption of grapefruit or grapefruit juice during treatment with MOVANTIK is to be avoided.1
IMPORTANT SAFETY INFORMATION ABOUT MOVANTIK
- MOVANTIK may cause serious side effects, including:
- Opioid withdrawal. You may have symptoms of opioid withdrawal during treatment with MOVANTIK, including sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning. Patients taking methadone to treat their pain may be more likely to experience stomach pain and diarrhea. Tell your doctor if you have any of these symptoms
- Severe Stomach Pain and/or Diarrhea. This can happen within a few days of starting MOVANTIK and can lead to hospitalization. If either of these side effects occurs, stop taking MOVANTIK and call your doctor immediately
- Tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that gets worse or does not go away, stop taking MOVANTIK and get emergency medical help right away
- Do not take MOVANTIK if you:
- Have a bowel blockage (intestinal obstruction) or have a history of bowel blockage
- Are allergic to MOVANTIK or any of the ingredients in MOVANTIK
- MOVANTIK can interact with other medicines and cause side effects, including opioid withdrawal symptoms (see symptoms above). Tell your doctor or pharmacist before you start or stop any medicines during treatment with MOVANTIK
- Before you take MOVANTIK, tell your doctor about all of your medical conditions, including if you:
- Have any stomach, bowel (intestines) problems, including inflammation in parts of the large intestine (diverticulitis), or inflammation and injury of the intestines caused by reduced blood flow (ischemic colitis)
- Have had recent surgery on the stomach or intestines
- Have any kidney, or liver problems
- Are pregnant or plan to become pregnant. Taking MOVANTIK during pregnancy may cause opioid withdrawal symptoms in you or your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with MOVANTIK
- Are breastfeeding or plan to breastfeed. It is not known if MOVANTIK passes into your breast milk. Taking MOVANTIK while you are breastfeeding may cause opioid withdrawal in your baby. You and your healthcare provider should decide if you will take MOVANTIK or breastfeed. You should not breastfeed if you take MOVANTIK
- Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect the way MOVANTIK works
- If you stop taking your opioid pain medicine, stop taking MOVANTIK and tell your doctor
- Avoid eating grapefruit or drinking grapefruit juice during treatment with MOVANTIK
- The most common side effects of MOVANTIK include: Stomach (abdomen) pain, diarrhea, nausea, gas, vomiting, headache, and excessive sweating
APPROVED USE FOR MOVANTIK
MOVANTIK is a prescription medicine used to treat constipation that is caused by prescription pain medicines called opioids, in adults with long-lasting (chronic) pain that is not caused by active cancer.
Click here for the Medication Guide and full Prescribing Information for MOVANTIK.
You are encouraged to report Adverse Reactions to RedHill Biopharma Inc. at 1-833-ADRHILL (1-833-237-4455) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
RedHill Biopharma Inc. supports the responsible use of medications, including those containing opioids, as treatment options for patients with chronic non-cancer pain.
This site is intended for US Consumers only.
The information on this website should not take the place of talking with your doctor or health care professional. If you have any questions about your condition, or if you would like more information about MOVANTIK, or about constipation caused by opioid use for chronic non-cancer pain, talk to your doctor or pharmacist. Only you and your doctor can decide if MOVANTIK is right for you.
RedHill Biopharma Inc. (U.S. Office)
8041 Arco Corporate Drive, Suite 200
Raleigh, NC 27617
Tel: +1-984-444-7010
Fax: +1-919-406-0400
info@redhillus.com
Think you have opioid-induced constipation?
Are you currently taking any opioid pain medication(s) for chronic non-cancer pain?
Select one
MOVANTIK is meant for people taking opioids in order to treat opioid-induced constipation in adults with chronic non-cancer pain.
If you’re experiencing constipation, talk to your doctor about your options for treatment.2,3
How many bowel movements do you have per week?
Select one
MOVANTIK is for the treatment of opioid-induced constipation in adults with chronic non-cancer pain. Having less than 3 bowel movements per week while taking opioids can be a symptom of opioid-induced constipation.
If you’re experiencing constipation, talk to your doctor
about your options for treatment.2,3
When completing a bowel movement, have you experienced any of the following?
Select all that apply
You may have opioid-induced constipation.1-3
Talk to you doctor about your symptoms and learn how
MOVANTIK may be able to help.
Coverage for the #1 prescribed oral
PAMORA just got even better1
*Data as of June 2021.3
Plans and coverage may vary and are subject to change. General information only, not a guarantee of coverage. Coverage and status do not imply efficacy or safety.
PAMORA=peripherally acting mu-opioid receptor antagonist; PDP=prescription drug plan.
References: 1. Data on file. Prescription data. RedHill Biopharma Inc; 2021. 2. Data on file. Prime Therapeutics formulary coverage. RedHill Biopharma Inc; 2021. 3. Data on file. Cigna formulary coverage. RedHill Biopharma Inc; 2021.